Located on the banks of the Nervion River and adjacent to the Guggenheim Museum, the Melia Bilbao is located in the center of Bilbao. Santiago Cathedral is 3 kilometers away and the Ereaga Beach is located at 12 kilometers distance. The Bilbao International Airport is located about 10 miles from the Melia Bilbao and there is public transportation nearby.

Each of the 211 rooms at the Melia Bilbao is air conditioned and provides an en suite bathroom with bidets, bathrobes and slippers, telephones, television, in-room movies, electronic safes, minibars, work desks and data port connections.

The Melia Bilbao offers a welcoming lobby with 24 hour reception to greet its guests. Some amenities on offer at the property are safe rentals, currency exchange, a bar, café, an onsite restaurant, outdoor swimming pool, fitness center, Internet capabilities, meeting and banquet halls, 24 hour room service and laundry service. Additionally, there is babysitting services offered and a covered parking facility for guests with cars. The staff can assist with making plans for any excursions.